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Lilly is studying retatrutide in several Phase 3 clinical trials to evaluate its potential efficacy and safety in obesity and overweight with at least one weight-related medical problem, type 2 diabetes, knee osteoarthritis, moderate-to-severe obstructive sleep apnea, chronic low back pain, cardiovascular and renal outcomes, and metabolic dysfunction-associated steatotic liver disease

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These results underscore Semaglutides ability to reshape body compositionnot just peel calories but shift dangerous fat stores for healthier outcomes

Additionally, regular physical activity has been shown to help reverse leptin resistance by improving insulin sensitivity and reducing inflammation

The experiment was repeated three times and the results were statistically analyzed using one-way ANOVA method following Tukey post-hoc hypothesis test